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Amplification of 2p as a genomic marker for transformation in lymphoma
- Source :
- Genes, Chromosomes & Cancer
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL (tDLBCL), and 21 antecedent FL]. In 15 patients, paired tumor samples (primary FL and a subsequent tDLBCL) were available, among which three possessed more than two subsequent tumors, allowing us to follow specific genetic alterations acquired before, during, and after the transformation. Gain of 2p15–16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P
- Subjects :
- Adult
Genetic Markers
Male
Cancer Research
Adolescent
Follicular lymphoma
Biology
Genome
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
CDKN2A
Genetics
medicine
Humans
Lymphoma, Follicular
Gene
Research Articles
Aged
Medicinsk genetik
030304 developmental biology
Aged, 80 and over
Chromosome Aberrations
Cancer och onkologi
0303 health sciences
NF-kappa B
Middle Aged
medicine.disease
Lymphoma
Transformation (genetics)
Genetic marker
Child, Preschool
Chromosomes, Human, Pair 2
Cancer and Oncology
030220 oncology & carcinogenesis
Disease Progression
Cancer research
Female
Lymphoma, Large B-Cell, Diffuse
Medical Genetics
Chromosomes, Human, Pair 17
Signal Transduction
Subjects
Details
- ISSN :
- 10982264 and 10452257
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi.dedup.....0c4dac6449afc52ff99ab239a8290565