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Amplification of 2p as a genomic marker for transformation in lymphoma

Authors :
Koichi Ichimura
Anna Kwiecinska
Luqman Sulaiman
Andrii Dinets
Svetlana Lagercrantz
Mattias Berglund
Anna Porwit
V. Peter Collins
Catharina Larsson
Source :
Genes, Chromosomes & Cancer
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL (tDLBCL), and 21 antecedent FL]. In 15 patients, paired tumor samples (primary FL and a subsequent tDLBCL) were available, among which three possessed more than two subsequent tumors, allowing us to follow specific genetic alterations acquired before, during, and after the transformation. Gain of 2p15–16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P

Details

ISSN :
10982264 and 10452257
Volume :
53
Database :
OpenAIRE
Journal :
Genes, Chromosomes and Cancer
Accession number :
edsair.doi.dedup.....0c4dac6449afc52ff99ab239a8290565