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A gain of function mutation in SlNRC4a enhances basal immunity resulting in broad-spectrum disease resistance
- Source :
- Communications Biology, Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Plants rely on innate immunity to perceive and ward off microbes and pests, and are able to overcome the majority of invading microorganisms. Even so, specialized pathogens overcome plant defenses, posing a persistent threat to crop and food security worldwide, raising the need for agricultural products with broad, efficient resistance. Here we report a specific mutation in a tomato (S. lycopersicum) helper nucleotide-binding domain leucine-rich repeat H-NLR, SlNRC4a, which results in gain of function constitutive basal defense activation, in absence of PRR activation. Knockout of the entire NRC4 clade in tomato was reported to compromise Rpi-blb2 mediated immunity. The SlNRC4a mutant reported here possesses enhanced immunity and disease resistance to a broad-spectrum of pathogenic fungi, bacteria and pests, while lacking auto-activated HR or negative effects on plant growth and crop yield, providing promising prospects for agricultural adaptation in the war against plant pathogens that decrease productivity.<br />Lorena Pizarro, Meirav Leibman-Markus et al. explore the genetic mechanisms for plant innate immunity. They functionally characterize a gain of function mutation in SlNRC4a in tomato. They characterize the structure of the mutant protein and functionally demonstrate that it confers broad-spectrum resistance without triggering a hypersensitive response or negatively impacting plant growth and crop yield.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Mutant
Medicine (miscellaneous)
Plant disease resistance
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
Article
Crop
03 medical and health sciences
Solanum lycopersicum
Immunity
Plant defense against herbivory
Plant Immunity
lcsh:QH301-705.5
Disease Resistance
Plant Diseases
Plant Proteins
Genetics
Pattern recognition receptors in plants
Innate immune system
biology
Virulence
fungi
food and beverages
biology.organism_classification
030104 developmental biology
lcsh:Biology (General)
Gain of Function Mutation
Adaptation
General Agricultural and Biological Sciences
Bacteria
010606 plant biology & botany
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....0c4a0d2010b10a3e12a5d135f0f28dbd