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Case Report: Combined Intravenous Infusion and Local Injection of CAR-T Cells Induced Remission in a Relapsed Diffuse Large B-Cell Lymphoma Patient
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Relapsed diffuse large B-cell lymphoma (DLBCL) is a disease with a poor prognosis. Recent clinical trials results showed chimeric antigen receptor (CAR) T cell therapy has a promising role in treating relapsed DLBCL. Unfortunately, patients with extranodal lesions respond poorly to CAR-T cells administered intravenously. Herein, we evaluated the efficacy and safety of a new treatment strategy of CAR-T cells, combining intravenous infusion with local injection of CAR-T cells, in a relapsed DLBCL patient with extranodal lesions. The patient achieved durable remission and without severe adverse effects after CAR-T cells treatment. During the follow-up period of one year, the patient remained in good condition. In conclusion, combining intravenous injection with a local injection for CAR-T cell is a feasible strategy for relapsed DLBCL patients with extranodal lesions.
- Subjects :
- medicine.medical_specialty
local injection
T cell
Immunology
diffuse large B-cell lymphoma
Gastroenterology
Extranodal Disease
hemic and lymphatic diseases
Internal medicine
medicine
case report
Immunology and Allergy
Adverse effect
extranodal disease
business.industry
RC581-607
chimeric antigen receptor T cell therapy
medicine.disease
Chimeric antigen receptor
Lymphoma
Clinical trial
medicine.anatomical_structure
Chimeric Antigen Receptor T-Cell Therapy
Immunologic diseases. Allergy
business
Diffuse large B-cell lymphoma
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....0c420bb144fbaab8226cd90a40ff6211