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Relationship between Circulating Platelet Counts and Ductus Arteriosus Patency after Indomethacin Treatment
- Source :
- The Journal of Pediatrics. 158:919-923.e2
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Objective To determine whether low platelet counts are related to the incidence of patent ductus arteriosus (PDA) after indomethacin treatment in preterm human infants. Study design Multivariable logistic regression modeling was used for a cohort of 497 infants, who received indomethacin (within 15 hours of birth). Results Platelet counts were not related to the incidence of permanent closure after indomethacin constriction. There was a relationship between platelet counts and the initial degree of constriction; however, this relationship appeared to be primarily influenced by the high end of the platelet distribution curve. PDA incidence was similar in infants with platelet counts 9 /L and those with platelet counts above this range. Only when platelet counts were consistently >230 ×10 9 /L was there a decrease in PDA incidence. Conclusion In contrast to the evidence in mice, low circulating platelet counts do not affect permanent ductus closure (or ductus reopening) in human preterm infants.
- Subjects :
- Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Time Factors
Indomethacin
Article
Constriction
Cohort Studies
Indometacin
Internal medicine
Ductus arteriosus
Humans
Medicine
Platelet
Ductus Arteriosus, Patent
Platelet Count
business.industry
Incidence (epidemiology)
Infant, Newborn
Cardiovascular Agents
Ductus Arteriosus
Treatment Outcome
medicine.anatomical_structure
Echocardiography
Tocolytic
Anesthesia
Pediatrics, Perinatology and Child Health
Cardiovascular agent
Cardiology
Regression Analysis
Female
business
Infant, Premature
medicine.drug
Cohort study
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....0c3a104e276164337876e1a12c2dc031