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Two cases of chronic graft-versus-host disease with elevated levels of soluble Fas ligand in serum
- Source :
- American journal of hematology. 64(2)
- Publication Year :
- 2000
-
Abstract
- It has recently been shown that the Fas-Fas ligand (FasL) system may be one of the pathogeneses for acute graft-versus-host disease (GVHD), and it has been reported that serum soluble Fas ligand (sFasL) increases with the presence of acute GVHD. However, there is no report on a correlation between the Fas-FasL system and chronic GVHD. We present two cases of chronic GVHD with elevated levels of serum sFasL. Its level in each case was high at the onset of chronic GVHD, but it decreased with steroid therapy. Liver dysfunction also improved as the level of serum sFasL decreased. It appears in these cases that the Fas-FasL system was related to the pathogenesis of liver damage.
- Subjects :
- Male
Fas Ligand Protein
Adolescent
Prednisolone
Graft vs Host Disease
chemical and pharmacologic phenomena
Disease
Fas ligand
Pathogenesis
immune system diseases
medicine
Humans
Membrane Glycoproteins
business.industry
Hematology
Middle Aged
medicine.disease
Ligand (biochemistry)
Soluble fas ligand
surgical procedures, operative
Graft-versus-host disease
Liver
Solubility
Immunology
Chronic Disease
Cyclosporine
Chronic gvhd
Female
Liver dysfunction
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 03618609
- Volume :
- 64
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of hematology
- Accession number :
- edsair.doi.dedup.....0c34592cb793593efa13a72cd44f8ba7