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Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy
- Source :
- Cancers, Cancers, Vol 11, Iss 10, p 1465 (2019)
- Publication Year :
- 2019
-
Abstract
- Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.
- Subjects :
- 0301 basic medicine
Cancer Research
autophagy
mTOR inhibitors
Cardiomyopathy
Review
lcsh:RC254-282
drugs
chloroquine
03 medical and health sciences
Liver disease
0302 clinical medicine
Chloroquine
medicine
cancer
business.industry
Autophagy
apoptosis
drug
Cancer
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
apoptosi
030104 developmental biology
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer research
business
Function (biology)
Intracellular
medicine.drug
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....0c31a7c7834a122970aa93010b80731a