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RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling
- Source :
- BioMed Research International, Vol 2020 (2020), BioMed Research International
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Osteoporosis
030209 endocrinology & metabolism
Review Article
Bioinformatics
Bone health
Bone and Bones
General Biochemistry, Genetics and Molecular Biology
Bone remodeling
Bone modeling
03 medical and health sciences
0302 clinical medicine
Bone Density
medicine
Humans
General Immunology and Microbiology
biology
Mechanism (biology)
business.industry
RANK Ligand
Osteoprotegerin
General Medicine
medicine.disease
Osteopenia
Bone Diseases, Metabolic
030104 developmental biology
RANKL
biology.protein
Medicine
Bone Remodeling
Organic component
business
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....0c2af89c8779282c1a2be09297974828