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Research Progress on the Interaction Between Autophagy and Energy Homeostasis in Cardiac Remodeling
- Source :
- Frontiers in Pharmacology, Vol 11 (2020), Frontiers in Pharmacology
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- Cardiac remodeling is a common pathological process in various heart diseases, such as cardiac hypertrophy, diabetes-associated cardiomyopathy and ischemic heart diseases. The inhibition of cardiac remodeling has been suggested to be a potential strategy for preventing heart failure. However, the mechanisms involved in cardiac remodeling are quite complicated. Recent studies have reported a close correlation between autophagy and energy homeostasis in cardiac remodeling associated with various heart diseases. In this review, we summarize the roles of autophagy and energy homeostasis in cardiac remodeling and discuss the relationship between these two processes in different conditions to identify potential targets and strategies for treating cardiac remodeling by regulating autophagy.
- Subjects :
- 0301 basic medicine
Ischemic Heart Diseases
autophagy
Cardiomyopathy
Review
030204 cardiovascular system & hematology
Bioinformatics
Energy homeostasis
03 medical and health sciences
0302 clinical medicine
Diabetic cardiomyopathy
Medicine
Pharmacology (medical)
Pathological
energy homeostasis
Pharmacology
ischemic heart diseases
business.industry
diabetes-associated cardiomyopathy
cardiac hypertrophy
Autophagy
lcsh:RM1-950
medicine.disease
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Cardiac hypertrophy
Heart failure
cardiovascular system
cardiac remodeling
business
Subjects
Details
- Language :
- English
- ISSN :
- 16639812
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....0c261b6734ee80e29be113d2613407cf
- Full Text :
- https://doi.org/10.3389/fphar.2020.587438