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A primer on current progress in cardiac fibrosis
- Source :
- Canadian Journal of Physiology and Pharmacology. 95:1091-1099
- Publication Year :
- 2017
- Publisher :
- Canadian Science Publishing, 2017.
-
Abstract
- Cardiac fibrosis is a significant global health problem that is closely associated with multiple forms of cardiovascular disease, including myocardial infarction, dilated cardiomyopathy, and diabetes. Fibrosis increases myocardial wall stiffness due to excessive extracellular matrix deposition, causing impaired systolic and diastolic function, and facilitating arrhythmogenesis. As a result, patient morbidity and mortality are often dramatically elevated compared with those with cardiovascular disease but without overt fibrosis, demonstrating that fibrosis itself is both a pathologic response to existing disease and a significant risk factor for exacerbation of the underlying condition. The lack of any specific treatment for cardiac fibrosis in patients suffering from cardiovascular disease is a critical gap in our ability to care for these individuals. Here we provide an overview of the development of cardiac fibrosis, and discuss new research directions that have recently emerged and that may lead to the creation of novel treatments for patients with cardiovascular diseases. Such treatments would, ideally, complement existing therapy by specifically focusing on amelioration of fibrosis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Exacerbation
Physiology
Cardiac fibrosis
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Fibrosis
Physiology (medical)
Internal medicine
Diabetes mellitus
medicine
Animals
Humans
Myocardial infarction
Myofibroblasts
Ventricular remodeling
Pharmacology
Ventricular Remodeling
business.industry
Myocardium
Dilated cardiomyopathy
General Medicine
Fibroblasts
medicine.disease
Extracellular Matrix
030104 developmental biology
Cardiology
Cardiomyopathies
business
Signal Transduction
Subjects
Details
- ISSN :
- 12057541 and 00084212
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Accession number :
- edsair.doi.dedup.....0c25cc8b24b80ca91b8b76c9b93fe9a9