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Virus infection in HLA-haploidentical hematopoietic stem cell transplantation: incidence in the context of immune recovery in two different transplantation settings

Authors :
Susanne Fritsch
Veit Bücklein
Georg Ledderose
Anna-K. Zoellner
Johanna Tischer
Roland Reibke
Wolfgang Hill
Hans Joachim Stemmler
Christina Rieger
Dusan Prevalsek
Thomas Köhnke
Gundula Jäger
Christoph Schulz
Friederike Mumm
Nicole Engel
Max Hubmann
Christoph Schmid
Andreas Hausmann
Hans-Jochem Kolb
Andreas Moosmann
Source :
Annals of Hematology. 94:1677-1688
Publication Year :
2015
Publisher :
Springer Science and Business Media LLC, 2015.

Abstract

We retrospectively compared the incidence of virus infections and outcome in the context of immune reconstitution in two different HLA-haploidentical transplantation (haplo-HSCT) settings. The first was a combined T-cell-replete and T-cell-deplete approach using antithymocyte globulin (ATG) prior to transplantation in patients with hematological diseases (cTCR/TCD group, 28 patients; median age 31 years). The second was a T-cell-replete (TCR) approach using high-dose posttransplantation cyclophosphamide (TCR/PTCY group, 27 patients; median age 43 years). The incidence of herpesvirus infection was markedly lower in the TCR/PTCY (22 %) than in the cTCR/TCD group (93 %). Recovery of CD4+ T cells on day +100 was faster in the TCR/PTCY group. CMV reactivation was 30 % in the TCR/PTCY compared to 57 % in the cTCR/TCD group, and control with antiviral treatment was superior after TCR/PTCY transplantation (100 vs 50 % cTCR/TCD). Twenty-five percent of the patients in the cTCR/TCD group but no patient in the TCR/PTCY group developed PTLD. While 1-year OS was not different (TCR/PTCY 59 % vs cTCR/TCD 39 %; p = 0.28), virus infection-related mortality (VIRM) was significantly lower after TCR/PTCY transplantation (1-year VIRM, 0 % TCR/PTCY vs 29 % cTCR/TCD; p = 0.009). On day +100, predictors of better OS were lymphocytes >300/μl, CD3+ T cells >200/μl, and CD4+ T cells >150/μl, whereas the application of steroids >1 mg/kg was correlated with worse outcome. Our results suggest that by presumably preserving antiviral immunity and allowing fast immune recovery of CD4+ T cells, the TCR approach using posttransplantation cyclophosphamide is well suited to handle the important issue of herpesvirus infection after haplo-HSCT.

Details

ISSN :
14320584 and 09395555
Volume :
94
Database :
OpenAIRE
Journal :
Annals of Hematology
Accession number :
edsair.doi.dedup.....0c1ed82e440348a3d5666232e594fecc