Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme

Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6±2.9 cM from the Mls locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: $${\text{Dip - 1 }}19.0 \pm 3.8\% {\text{Lp }}7.4 \pm 2.2\% {\text{Akp - 1}}$$