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A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke
- Source :
- The Journal of neuropsychiatry and clinical neurosciences. 5(4)
- Publication Year :
- 1993
-
Abstract
- Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neuropsychological Tests
Serotonergic
behavioral disciplines and activities
Serotonin Receptor Binding
Radioligand Assay
Cognition
Internal medicine
medicine
Humans
Effects of sleep deprivation on cognitive performance
Stroke
5-HT receptor
Aged
Cerebral Cortex
medicine.diagnostic_test
business.industry
Neuropsychological test
Middle Aged
medicine.disease
Psychiatry and Mental health
Cerebrovascular Disorders
Serotonin binding
Endocrinology
medicine.anatomical_structure
Cerebral cortex
Receptors, Serotonin
Female
Neurology (clinical)
business
Neuroscience
Subjects
Details
- ISSN :
- 08950172
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of neuropsychiatry and clinical neurosciences
- Accession number :
- edsair.doi.dedup.....0c19f579f43da6aa6ab7904c12c7f26b