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The Duration of Neonatal Phototherapy and Allergic Disorders: The Japan Environment and Children’s Study

Authors :
Masashi, Hotta
Kimiko, Ueda
Satoyo, Ikehara
Kanami, Tanigawa
Hirofumi, Nakayama
Kazuko, Wada
Tadashi, Kimura
Keiichi, Ozono
Tomotaka, Sobue
Hiroyasu, Iso
Source :
International Archives of Allergy and Immunology. 184:211-219
Publication Year :
2022
Publisher :
S. Karger AG, 2022.

Abstract

Introduction: Currently, the association between the duration of neonatal phototherapy and the risk of allergic disorders has not been reported. This observational cohort study aimed to examine the association between allergic disorders, including food allergies, that are present before 3 years of age and the duration of phototherapy using the nationwide birth cohort data. Methods: The Japan Environment and Children’s Study was a nationwide birth cohort study. Data of 77,064 infants aged 1 year, 1.5 years, 2 years, and 3 years were analyzed. We divided the participants into three groups: no phototherapy, short phototherapy (1–24 h), and long phototherapy (>24 h) and evaluated the cumulative incidence of allergic disorders before 3 years of age, including asthma, atopic dermatitis, and food allergies. Logistic regression analysis was performed to assess the impact of phototherapy duration on the cumulative incidence of allergic disorders. Results: After adjustment for potential risk factors, long phototherapy was found to be positively associated with food allergies at age 2 years (OR: 1.16; 95% CI: 1.01–1.33) and all allergic disorders at age 3 years (OR: 1.12; 95% CI: 1.01–1.24), including food allergies (OR 1.18; 95% CI: 1.04–1.35). Conclusion: A long duration of neonatal phototherapy was positively associated with the risk of allergic disorders, especially food allergies.

Details

ISSN :
14230097 and 10182438
Volume :
184
Database :
OpenAIRE
Journal :
International Archives of Allergy and Immunology
Accession number :
edsair.doi.dedup.....0c114f601dfc4ba3dbb5da9b8ee535bf
Full Text :
https://doi.org/10.1159/000527381