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fMRI pain activation in the periaqueductal gray in healthy volunteers during the cold pressor test
- Publication Year :
- 2014
- Publisher :
- ELSEVIER SCIENCE INC, 2014.
-
Abstract
- The periaqueductal gray (PAG), a brain area belonging to the descending pain modulatory system, plays a crucial role in pain perception. Little information is available on the relationship between PAG activation and perceived pain intensity. In this study, we acquired functional magnetic resonance imaging (fMRI) scans from the PAG during the cold pressor test, a model for tonic pain, in 12 healthy volunteers. fMRI data were acquired with a 12-channel head-coil and a 3-Tesla scanner and analyzed with Statistical Parametric Mapping (SPM8) software. During the cold pressor test, fMRI showed significant activation clusters in pain-related brain areas: bilateral middle and superior frontal gyrus, anterior cingulate cortex and thalamus, left insula, right inferior frontal gyrus, left inferior temporal gyrus and in the bilateral PAG (cluster level corrected threshold p
- Subjects :
- Adult
medicine.medical_specialty
Thalamus
Biomedical Engineering
Biophysics
Statistical parametric mapping
Periaqueductal gray
Sensitivity and Specificity
Reference Values
Internal medicine
Threshold of pain
medicine
Humans
Periaqueductal Gray
Radiology, Nuclear Medicine and imaging
Anterior cingulate cortex
Brain Mapping
medicine.diagnostic_test
business.industry
Cold pressor test
Reproducibility of Results
Settore MED/37 - Neuroradiologia
Pain Perception
Magnetic Resonance Imaging
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Cold Temperature
medicine.anatomical_structure
nervous system
Superior frontal gyrus
Anesthesia
Cardiology
methods
nerve net
reference values
cold pressor test
fibromyalgia
periacqueductal gray
reproducibility of results
magnetic resonance imaging
adult
humans
sensitivity and specificity
periaqueductal gray
fmri
physiology
brain mapping
cold temperature
pain perception
diagnostic use
descending modulatory system
Nerve Net
Functional magnetic resonance imaging
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0c0edd04db0894e52781ff8f5c1e557a