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Monomethylthio analogs of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane
- Source :
- Journal of Medicinal Chemistry. 20:1235-1239
- Publication Year :
- 1977
- Publisher :
- American Chemical Society (ACS), 1977.
-
Abstract
- Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM).
- Subjects :
- Male
Hyperthermia
Time Factors
Chemical Phenomena
Stereochemistry
Kinetics
Stereoisomerism
Body Temperature
Structure-Activity Relationship
chemistry.chemical_compound
Isomerism
Drug Discovery
medicine
Animals
Potency
Structure–activity relationship
2,5-Dimethoxy-4-Methylamphetamine
Chemistry
Amphetamines
2,5-Dimethoxy-4-methylamphetamine
Brain
Psychotomimetic
medicine.disease
Rats
Molecular Medicine
Rabbits
Enantiomer
medicine.drug
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....0bf166f3eb638e6252c666cb353aab87