Back to Search
Start Over
Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect:A long-term follow-up
- Source :
- Eckerström, F, Rex, C E, Maagaard, M, Heiberg, J, Rubak, S, Redington, A & Hjortdal, V E 2020, ' Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect : A long-term follow-up ', International Journal of Cardiology, vol. 306, pp. 168-174 . https://doi.org/10.1016/j.ijcard.2020.02.069
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: There are increasing reports of cardiac and exercise dysfunction in adults with small, unrepaired ventricular septal defects (VSDs). The primary aim of this study was to evaluate pulmonary function in adults with unrepaired VSDs, and secondly to assess the effects of 900 μg salbutamol on lung function and exercise capacity.METHODS: Young adult patients with small, unrepaired VSDs and healthy age- and gender-matched controls were included in a double-blinded, randomised, cross-over study. Participants underwent static and dynamic spirometry, impulse oscillometry, multiple breath washout, diffusion capacity for carbon monoxide, and ergometer bicycle cardiopulmonary exercise test.RESULTS: We included 30 patients with VSD (age 27 ± 6 years) and 30 controls (age 27 ± 6 years). Patients tended to have lower FEV1, 104 ± 11% of predicted, compared with healthy controls, 110 ± 14% (p = 0.069). Furthermore, the patient group had lower peak expiratory flow (PEF), 108 ± 20% predicted, compared with the control group, 118 ± 17% (p = 0.039), and showed tendencies towards lower forced vital capacity and increased airway resistance compared with controls. During exercise, the patients had lower oxygen uptake, 35 ± 8 ml/min/kg (vs 47 ± 7 ml/min/kg, p CONCLUSION: At rest, young adults with unrepaired VSDs are no different in pulmonary function from controls. However, when the cardiorespiratory system is stressed, VSD patients demonstrate significantly impaired minute ventilation and peak oxygen uptake, which may be early signs of parenchymal dysfunction and restrictive airway disease. These abnormalities were unaffected by the inhalation of salbutamol.
- Subjects :
- Adult
Heart Septal Defects, Ventricular
Spirometry
medicine.medical_specialty
Vital capacity
030204 cardiovascular system & hematology
Ventricular septal defect
Pulmonary function testing
Young Adult
03 medical and health sciences
0302 clinical medicine
Airway resistance
Internal medicine
medicine
Humans
Adult congenital heart disease
030212 general & internal medicine
Long-term follow-up
Cross-Over Studies
Exercise Tolerance
medicine.diagnostic_test
business.industry
VO2 max
Cardiorespiratory fitness
Case-Control Studies
Exercise Test
Salbutamol
Cardiology
Cardiopulmonary function
Cardiology and Cardiovascular Medicine
business
Respiratory minute volume
Follow-Up Studies
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Eckerström, F, Rex, C E, Maagaard, M, Heiberg, J, Rubak, S, Redington, A & Hjortdal, V E 2020, ' Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect : A long-term follow-up ', International Journal of Cardiology, vol. 306, pp. 168-174 . https://doi.org/10.1016/j.ijcard.2020.02.069
- Accession number :
- edsair.doi.dedup.....0bf109e08ab016b805b620390e87e200