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Vasomotor reactivity and catecholamine, arginine vasopressin plasma levels during ageing and development in rats
- Source :
- Mechanisms of ageing and development. 77(1)
- Publication Year :
- 1994
-
Abstract
- Vascular reactivity, heart rate responses to vasoconstrictor and/or vasodilatator agents and catecholamine and arginine vasopressin turnover were studied in normotensive Wistar Kyoto (WKY), spontaneously hypertensive (SHR), normolipemic Brown Norway (BN) and spontaneously hyperlipemic Yoshida (YOS) anaesthetized rats at 2, 6 and 18 months of age. In this study, we investigated whether ageing and development could affect cardiovascular reactivity to vasoactive substances and catecholamine and arginine vasopressin turnover. No significant changes in the pressor responses to noradrenaline and to carotid sinus baroreceptor stimulation were observed nor were there significant alterations in reflex tachycardia and bradycardia. Arginine vasopressin plasma levels also did not change with ageing and development. On the other hand, the hypotensive responses to isoprenaline decreased in old rats, acetylcholine relaxation effect increased with ageing and development in some rat strains (BN and YOS) and catecholamine plasma levels increased with ageing and development. Our results indicate that during ageing and development, vascular responsiveness to vasoconstrictor and/or vasodilatator agents, as well as amine turnover, may increase, decrease or not change at all depending on the neurotransmission system studied, and on the experimental model and/or animal tested.
- Subjects :
- Carotid Artery Diseases
Vasopressin
medicine.medical_specialty
Aging
Arginine
Vasopressins
Stimulation
Arterial Occlusive Diseases
Blood Pressure
Hyperlipidemias
Norepinephrine
Catecholamines
Isoprenaline
Internal medicine
medicine
Animals
Vasoconstrictor Agents
Chemistry
Carotid sinus
Isoproterenol
Rats, Inbred Strains
Acetylcholine
Rats
Vasomotor System
Endocrinology
medicine.anatomical_structure
Ageing
Hypertension
cardiovascular system
Catecholamine
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00476374
- Volume :
- 77
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Mechanisms of ageing and development
- Accession number :
- edsair.doi.dedup.....0be5f54c61289276d41eac3f0acab0e6