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Evaluation of deformable image registration algorithm for determination of accumulated dose for brachytherapy of cervical cancer patients
- Source :
- Journal of Contemporary Brachytherapy, Vol 11, Iss 5, Pp 469-478 (2019), Journal of Contemporary Brachytherapy
- Publication Year :
- 2019
- Publisher :
- Termedia Sp. z.o.o., 2019.
-
Abstract
- Purpose This study was designed to assess the dose accumulation (DA) of bladder and rectum between brachytherapy fractions using hybrid-based deformable image registration (DIR) and compare it with the simple summation (SS) approach of GEC-ESTRO in cervical cancer patients. Material and methods Patients (n = 137) with cervical cancer treated with 3D conformal radiotherapy and three fractions of high-dose-rate brachytherapy were selected. CT images were acquired to delineate organs at risk and targets according to GEC-ESTRO recommendations. In order to determine the DA for the bladder and rectum, hybrid-based DIR was done for three different fractions of brachytherapy and the results were compared with the standard GEC-ESTRO method. Also, we performed a phantom study to calculate the uncertainty of the hybrid-based DIR algorithm for contour matching and dose mapping. Results The mean ± standard deviation (SD) of the Dice similarity coefficient (DICE), Jaccard, Hausdorff distance (HD) and mean distance to agreement (MDA) in the DIR process were 0.94 ±0.02, 0.89 ±0.03, 8.44 ±3.56 and 0.72 ±0.22 for bladder and 0.89 ±0.05, 0.80 ±0.07, 15.46 ±10.14 and 1.19 ±0.59 for rectum, respectively. The median (Q1, Q3; maximum) GyEQD2 differences of total D2cc between DIR-based and SS methods for the bladder and rectum were reduced by -1.53 (-0.86, -2.98; -9.17) and -1.38 (-0.80, -2.14; -7.11), respectively. The mean ± SD of DICE, Jaccard, HD, and MDA for contour matching were 0.98 ±0.008, 0.97 ±0.01, 2.00 ±0.70 and 0.20 ±0.04, respectively for large deformation. Maximum uncertainty of dose mapping was about 3.58%. Conclusions The hybrid-based DIR algorithm demonstrated low registration uncertainty for both contour matching and dose mapping. The DA difference between DIR-based and SS approaches was statistically significant for both bladder and rectum and hybrid-based DIR showed potential to assess DA between brachytherapy fractions.
- Subjects :
- 0106 biological sciences
Jaccard index
medicine.medical_treatment
brachytherapy
Brachytherapy
lcsh:Medicine
Rectum
Image registration
01 natural sciences
Imaging phantom
Standard deviation
cervix
medicine
Radiology, Nuclear Medicine and imaging
deformable image registration
Cervical cancer
Original Paper
Image registration algorithm
business.industry
lcsh:R
010401 analytical chemistry
hdr
medicine.disease
0104 chemical sciences
medicine.anatomical_structure
Oncology
business
Nuclear medicine
010606 plant biology & botany
Subjects
Details
- ISSN :
- 1689832X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Contemporary Brachytherapy
- Accession number :
- edsair.doi.dedup.....0bddaf7a13742feb5264e4071176f6b6