Back to Search
Start Over
Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
- Source :
- JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 748-756 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.
- Subjects :
- lcsh:Diseases of the circulatory (Cardiovascular) system
Therapeutic effectiveness
microbubble
030204 cardiovascular system & hematology
Article
velocity time integral
03 medical and health sciences
0302 clinical medicine
medicine
Effective treatment
030212 general & internal medicine
Arterial injury
ultrasound
business.industry
Ultrasound
Vasospasm
N (ω)-nitro-L-arginine methyl ester
medicine.disease
Peripheral
lcsh:RC666-701
Anesthesia
catheter-induced vasospasm
Cardiology and Cardiovascular Medicine
Complication
business
Mechanical index
Subjects
Details
- ISSN :
- 2452302X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- JACC: Basic to Translational Science
- Accession number :
- edsair.doi.dedup.....0bdb0eae66cc0d7aea4b70fedc92e3ae