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Immunological deficiencies: more frequent than they seem to be
- Source :
- Jornal de Pediatria v.97 suppl.1 2021, Jornal de Pediatria, Sociedade Brasileira de Pediatria (SBP), instacron:SBPE, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Jornal de Pediatria, Volume: 97 Supplement 1, Pages: 49-58, Published: 26 APR 2021, Jornal de Pediatria, Vol 97, Iss, Pp S49-S58 (2021)
- Publication Year :
- 2021
- Publisher :
- Sociedade Brasileira de Pediatria, 2021.
-
Abstract
- Objective A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Epidemiology
MEDLINE
CORONAVIRUS
03 medical and health sciences
0302 clinical medicine
Immune system
Recurrence
Immunity
030225 pediatrics
Suspected diagnosis
Humans
Medicine
Pediatrics, Perinatology, and Child Health
030212 general & internal medicine
Symptom onset
Intensive care medicine
business.industry
SARS-CoV-2
Immunodeficiency disorders
Immunologic Deficiency Syndromes
lcsh:RJ1-570
COVID-19
lcsh:Pediatrics
Classification
Review article
Pediatrics, Perinatology and Child Health
Primary immunodeficiency disorders
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Jornal de Pediatria v.97 suppl.1 2021, Jornal de Pediatria, Sociedade Brasileira de Pediatria (SBP), instacron:SBPE, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Jornal de Pediatria, Volume: 97 Supplement 1, Pages: 49-58, Published: 26 APR 2021, Jornal de Pediatria, Vol 97, Iss, Pp S49-S58 (2021)
- Accession number :
- edsair.doi.dedup.....0bd192ae5c08d3f86e3cefd771cd8a7a