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Nonlinear cancer chemotherapy: Modelling the Norton-Simon hypothesis
- Source :
- Communications in Nonlinear Science and Numerical Simulation. 70:307-317
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A fundamental model of tumor growth in the presence of cytotoxic chemotherapeutic agents is formulated. The model allows to study the role of the Norton-Simon hypothesis in the context of dose-dense chemotherapy. Dose-dense protocols aim at reducing the period between courses of chemotherapy from three weeks to two weeks, in order to avoid tumor regrowth between cycles. We address the conditions under which these protocols might be more or less beneficial in comparison to less dense settings, depending on the sensitivity of the tumor cells to the cytotoxic drugs. The effects of varying other parameters of the protocol, as for example the duration of each continuous drug infusion, are also inspected. We believe that the present model might serve as a foundation for the development of more sophisticated models for cancer chemotherapy.
- Subjects :
- Oncology
Numerical Analysis
medicine.medical_specialty
Chemotherapy
Cancer chemotherapy
business.industry
Applied Mathematics
medicine.medical_treatment
Populations and Evolution (q-bio.PE)
Quantitative Biology - Tissues and Organs
Context (language use)
Tumor cells
Drug infusion
01 natural sciences
010305 fluids & plasmas
FOS: Biological sciences
Modeling and Simulation
Internal medicine
0103 physical sciences
medicine
Tumor growth
Quantitative Biology - Populations and Evolution
Tissues and Organs (q-bio.TO)
010306 general physics
business
Subjects
Details
- ISSN :
- 10075704
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Communications in Nonlinear Science and Numerical Simulation
- Accession number :
- edsair.doi.dedup.....0bd088f74f244921c1ed3bf7cde625d2