Back to Search
Start Over
Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
- Source :
- PLoS ONE, Vol 6, Iss 3, p e17291 (2011), PLoS ONE
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 resistance is important for the development of HIV-1 vaccines and Acquired Immune Deficiency Syndrome (AIDS) therapies. In this study, we analyzed the gene expression profiles of CD4+ T cells from HIV-1-resistant individuals and HIV-susceptible individuals. One hundred eighty-five discriminative HIV-1 resistance genes were identified using the Minimum Redundancy-Maximum Relevance (mRMR) and Incremental Feature Selection (IFS) methods. The virus protein target enrichment analysis of the 185 HIV-1 resistance genes suggested that the HIV-1 protein nef might play an important role in HIV-1 infection. Moreover, we identified 29 infection information exchanger genes from the 185 HIV-1 resistance genes based on a virus-host interaction network analysis. The infection information exchanger genes are located on the shortest paths between virus-targeted proteins and are important for the coordination of virus infection. These proteins may be useful targets for AIDS prevention or therapy, as intervention in these pathways could disrupt communication with virus-targeted proteins and HIV-1 infection.
- Subjects :
- Human Immunodeficiency Virus Proteins
Genetic Networks
Biochemistry
Immunodeficiency Viruses
Gene expression
Genetics
Multidisciplinary
virus diseases
Genomics
Host-Pathogen Interaction
Host-Pathogen Interactions
Infectious diseases
Medicine
Disease Susceptibility
Research Article
Mechanisms of Resistance and Susceptibility
Science
Immunology
HIV prevention
Retrovirology and HIV immunopathogenesis
Viral diseases
Biology
Microbiology
Virus
Acquired immunodeficiency syndrome (AIDS)
Interaction network
Genome Analysis Tools
HIV Seronegativity
Virology
Retroviruses
medicine
Humans
Gene Networks
Protein Interactions
Gene
Immunity to Infections
Mechanism (biology)
Gene Expression Profiling
Immunity
Computational Biology
Proteins
HIV
medicine.disease
Gene expression profiling
Viral Classification
HIV-1
Viral Transmission and Infection
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....0bce46dc7b403fbe1ad73166509bbf7b