TrMab-6 Exerts Antitumor Activity in Mouse Xenograft Models of Breast Cancers

Authors :: Tomohiro Tanaka
Tomokazu Ohishi
Masaki Saito
Manabu Kawada
Mika K. Kaneko
Yukinari Kato
Source :: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 41:32-38
Publication Year :: 2022
Publisher :: Mary Ann Liebert Inc, 2022.
Abstract: Trophoblast cell surface antigen 2 (TROP2) has been reported to be overexpressed in many cancers, and is involved in cancer cell proliferation, invasion, and metastasis. We previously developed a highly sensitive anti-TROP2 monoclonal antibody (mAb) (clone TrMab-6; mouse IgG