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Clever-1 positive macrophages in breast cancer
- Source :
- Breast Cancer Research and Treatment. 195:237-248
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Purpose Common Lymphatic Endothelial and Vascular Endothelial Receptor 1 (Clever-1) is expressed by a subset of immunosuppressive macrophages and targeting the receptor with therapeutic antibodies has been shown to activate T-cell-mediated anti-cancer immunity. The aim of this research was to study Clever-1 expression in breast cancer. Specifically, how Clever-1 + macrophages correlate with clinicopathologic factors, Tumor Infiltrating Lymphocytes (TILs) and prognosis. Methods Tissue microarray blocks were made from 373 primary breast cancer operation specimens. Hematoxylin and Eosin (H&E-staining) and immunohistochemical staining with Clever-1, CD3, CD4 and CD8 antibodies were performed. Differences in quantities of Clever-1 + macrophages and TILs were analyzed. Clever-1 + cell numbers were correlated with 25-year follow-up survival data and with breast cancer clinicopathologic parameters. Results Low numbers of intratumoral Clever-1 + cells were found to be an independent adverse prognostic sign. Increased numbers of Clever-1 + cells were found in high grade tumors and hormone receptor negative tumors. Tumors that had higher amounts of Clever-1 + cells also tended to have higher amounts of TILs. Conclusion The association of intratumoral Clever-1 + macrophages with better prognosis might stem from the function of Clever as a scavenger receptor that modulates tumor stroma. The association of Clever-1 + macrophages with high number of TILs and better prognosis indicates that immunosuppression by M2 macrophages is not necessarily dampening adaptive immune responses but instead keeping them in control to avoid excess inflammation.
- Subjects :
- EXPRESSION
Cancer Research
Macrophages
Tumor-associated macrophages
3122 Cancers
Breast Neoplasms
CD8-Positive T-Lymphocytes
Prognosis
Tumor infiltrating lymphocytes
Lymphocytes, Tumor-Infiltrating
Breast cancer
Oncology
RECEPTOR STABILIN-1
SURVIVAL
Humans
Female
Tumor stroma
TUMOR-INFILTRATING LYMPHOCYTES
Clever-1
Lymphatic Vessels
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 195
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....0bb26674f5a7fb5739e558192739d2f8