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Compound ex vivo and in silico method for hemodynamic analysis of stented arteries
- Source :
- PLoS ONE, 8 (3), PLoS ONE, Vol 8, Iss 3, p e58147 (2013), PLoS ONE
- Publication Year :
- 2013
-
Abstract
- Hemodynamic factors such as low wall shear stress have been shown to influence endothelial healing and atherogenesis in stent-free vessels. However, in stented vessels, a reliable quantitative analysis of such relations has not been possible due to the lack of a suitable method for the accurate acquisition of blood flow. The objective of this work was to develop a method for the precise reconstruction of hemodynamics and quantification of wall shear stress in stented vessels. We have developed such a method that can be applied to vessels stented in or ex vivo and processed ex vivo. Here we stented the coronary arteries of ex vivo porcine hearts, performed vascular corrosion casting, acquired the vessel geometry using micro-computed tomography and reconstructed blood flow and shear stress using computational fluid dynamics. The method yields accurate local flow information through anatomic fidelity, capturing in detail the stent geometry, arterial tissue prolapse, radial and axial arterial deformation as well as strut malapposition. This novel compound method may serve as a unique tool for spatially resolved analysis of the relationship between hemodynamic factors and vascular biology. It can further be employed to optimize stent design and stenting strategies.<br />PLoS ONE, 8 (3)<br />ISSN:1932-6203
- Subjects :
- Anatomy and Physiology
Swine
medicine.medical_treatment
Hemodynamics
Coronary Artery Disease
Cardiovascular
Cardiovascular System
Biophysics Simulations
10052 Institute of Physiology
Engineering
Restenosis
Biological Fluid Mechanics
Biomechanics
Cardiovascular Imaging
Multidisciplinary
Chemistry
Models, Cardiovascular
Arteries
Coronary Vessels
surgical procedures, operative
medicine.anatomical_structure
10209 Clinic for Cardiology
Medicine
Stents
Shear Strength
Blood Flow Velocity
Research Article
medicine.medical_specialty
Science
Biophysics
Biomedical Engineering
Bioengineering
610 Medicine & health
Fluid Mechanics
1100 General Agricultural and Biological Sciences
Medical Devices
Blood vessel prosthesis
1300 General Biochemistry, Genetics and Molecular Biology
medicine
Shear stress
Animals
Computer Simulation
cardiovascular diseases
Biology
Computerized Simulations
1000 Multidisciplinary
Mechanical Engineering
Stent
Blood flow
Atherosclerosis
equipment and supplies
medicine.disease
Blood Vessel Prosthesis
Surgery
Coronary arteries
Regional Blood Flow
Computer Science
570 Life sciences
biology
Fluid Physiology
Stress, Mechanical
Ex vivo
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 8 (3), PLoS ONE, Vol 8, Iss 3, p e58147 (2013), PLoS ONE
- Accession number :
- edsair.doi.dedup.....0badee87639180d04c7b137d48e58976