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Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy
- Source :
- Angewandte Chemie (International Ed. in English)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- The direct visualization of vaccine fate is important to investigate its immunoactivation process to elucidate the detailed molecular reaction process at single‐molecular level. Yet, visualization of the spatiotemporal trafficking of vaccines remains poorly explored. Here, we show that quantum dot (QD) nanomaterials allow for monitoring vaccine dynamics and for amplified immune response. Synthetic QDs enable efficient conjugation of antigen and adjuvants to target tissues and cells, and non‐invasive imaging the trafficking dynamics to lymph nodes and cellular compartments. The nanoparticle vaccine elicits potent immune responses and anti‐tumor efficacy alone or in combination with programmed cell death protein 1 blockade. The synthetic QDs showed high fluorescence quantum yield and superior photostability, and the reliable and long‐term spatiotemporal tracking of vaccine dynamics was realized for the first time by using the synthetic QDs, providing a powerful strategy for studying immune response and evaluating vaccine efficacy.<br />Visualization of spatiotemporal trafficking of vaccines is achieved with synthetic QDs for potent immune activation.
- Subjects :
- medicine.medical_treatment
Vaccine Efficacy
Computational biology
Nanovaccines
Catalysis
immune response
Immune system
Antigen
Programmed cell death 1
Quantum Dots
medicine
Humans
Research Articles
Vaccines
biology
nanotechnology
Chemistry
Dynamics (mechanics)
imaging
General Chemistry
Immunotherapy
General Medicine
Vaccine efficacy
Visualization
Quantum dot
biology.protein
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15213773 and 14337851
- Volume :
- 60
- Issue :
- 45
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie (International Ed. in English)
- Accession number :
- edsair.doi.dedup.....0b8d6dc4bce8f8fcbaad780b40f57c48