Back to Search
Start Over
[Expression of ganglioside GD2 on colorectal adenocarcinoma cells]
- Source :
- Biomeditsinskaia khimiia. 66(1)
- Publication Year :
- 2020
-
Abstract
- Using flow cytometry GD2 ganglioside expression was evaluated both on colorectal adenocarcinoma cell lines and on tumor tissue samples from colorectal cancer patients. The marker was found on EpCAM-positive tumor cells in 6 of 12 patients' samples but not on the HT29 and CaCo-2 cell lines. GD2 expression was not an exceptional feature of cancer stem cells, since its expression level was similar on CD133-positive and CD133-negative tumor cells. Thus, the presence of GD2 ganglioside was revealed on colorectal adenocarcinoma cells for the first time. This finding makes it possible to use targeted therapy to treat this disease.Metodom protochnoĭ tsitometrii issledovana ékspressiia gangliozida GD2 na kletkakh liniĭ kolorektal'noĭ adenokartsinomy HT29 i CaCo-2, a takzhe na obraztsakh opukholevoĭ tkani ot bol'nykh kolorektal'nym rakom. Issleduemyĭ marker fakticheski otsutstvoval na kletochnykh liniiakh, no ékspressirovalsia na EpCAM-pozitivnykh opukholevykh kletkakh u 6 iz 12 patsientov. Ékspressiia GD2 ne byla assotsiirovana s subpopuliatsieĭ rakovykh stvolovykh kletok, poskol'ku uroven' ego ékspressii ne otlichalsia na CD133-pozitivnykh i CD133-negativnykh kletkakh. Takim obrazom, vpervye vyiavleno prisutstvie gangliozida GD2 na kletkakh kolorektal'noĭ adenokartsinomy, chto otkryvaet vozmozhnost' ispol'zovaniia targetnoĭ terapii dlia lecheniia étogo zabolevaniia.
- Subjects :
- 0301 basic medicine
Colorectal cancer
medicine.medical_treatment
Clinical Biochemistry
Adenocarcinoma
Biochemistry
General Biochemistry, Genetics and Molecular Biology
GD2-ganglioside
Flow cytometry
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Gangliosides
medicine
Humans
Colorectal adenocarcinoma
Ganglioside
medicine.diagnostic_test
business.industry
General Medicine
medicine.disease
030104 developmental biology
Cell culture
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Caco-2 Cells
business
Colorectal Neoplasms
HT29 Cells
Subjects
Details
- ISSN :
- 23106972
- Volume :
- 66
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biomeditsinskaia khimiia
- Accession number :
- edsair.doi.dedup.....0b84d605308567d18e1d7b133b008ebb