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Promotion of strand invasion by utilizing entropically-favored PNA
- Source :
- Scopus-Elsevier
- Publication Year :
- 2009
- Publisher :
- Oxford University Press (OUP), 2009.
-
Abstract
- Invasion of peptide nucleic acid (PNA) is important to target a specific site in double-stranded DNA. However, it needs improvement in many ways such as sequence versatility and invasion efficiency. It is here reported that one 10-mer strand of alpha-lysine substituted peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in the presence of single-strand binding protein (SSB) via Watson-Crick rule. According to the thermodynamic parameters in this study, highly efficient invasion was achieved by a favorable entropy change. The importance of preorganization of PNAs for efficient strand invasion is indicated.
Details
- ISSN :
- 17468272 and 02613166
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Symposium Series
- Accession number :
- edsair.doi.dedup.....0b763e1c0fed3a59a861456639bd1faf