Back to Search
Start Over
A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials
- Source :
- Brain-A Journal of Neurology, Brain-A Journal of Neurology, Oxford University Press (OUP), In press, ⟨10.1093/brain/awab362⟩, BRAIN, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Brain, Brain-A Journal of Neurology, 2022, 145 (5), pp.1653-1667. ⟨10.1093/brain/awab362⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical evoked potentials provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies. Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the cortico-cortical evoked potentials recorded in a large multicentric database. Specifically, we considered each cortico-cortical evoked potential as the output of a transient stimulus entering the stimulated region, which directly propagated to the recording region. Both regions were modelled as coupled neural mass models, the parameters of which were estimated from the first cortico-cortical evoked potential component, occurring before 80 ms, using dynamic causal modelling and Bayesian model inversion. This methodology was applied to the data of 780 patients with epilepsy from the F-TRACT database, providing a total of 34 354 bipolar stimulations and 774 445 cortico-cortical evoked potentials. The cortical mapping of the local excitatory and inhibitory synaptic time constants and of the axonal conduction delays between cortical regions was obtained at the population level using anatomy-based averaging procedures, based on the Lausanne2008 and the HCP-MMP1 parcellation schemes, containing 130 and 360 parcels, respectively. To rule out brain maturation effects, a separate analysis was performed for older (>15 years) and younger patients (
- Subjects :
- neural mass models
0303 health sciences
Brain Mapping
Epilepsy
cortico-cortical evoked potential
Brain
Bayes Theorem
Electric Stimulation
dynamic causal modelling
03 medical and health sciences
0302 clinical medicine
axonal conduction delay
Humans
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurology (clinical)
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
synaptic time constant
Evoked Potentials
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 00068950 and 14602156
- Database :
- OpenAIRE
- Journal :
- Brain-A Journal of Neurology, Brain-A Journal of Neurology, Oxford University Press (OUP), In press, ⟨10.1093/brain/awab362⟩, BRAIN, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Brain, Brain-A Journal of Neurology, 2022, 145 (5), pp.1653-1667. ⟨10.1093/brain/awab362⟩
- Accession number :
- edsair.doi.dedup.....0b6ecf5a5f76c482faf35ba94e79416d