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A cross-sectional and longitudinal study evaluating brain volumes, RNFL, and cognitive functions in MS patients and healthy controls
- Source :
- BMC Neurology, BMC Neurology, Vol 18, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
-
Abstract
- Background The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and longitudinal assessment of the relationship between RNFL, cognitive functions and brain volume. Methods At baseline, relapsing patients and healthy controls underwent 1.5 T MRI to estimate the normalized volume of brain (NBV), grey (NGV), white (NWV) and peripheral grey (pNGV) matter. Cognitive functions were evaluated by BICAMS, RNFL by Spectral-Domain OCT. Patients were re-evaluated after 12 months. Results Cognitive functions, brain volume, and RNFL differed between the group of 66 patients and that of 16 healthy controls. In the MS group, at baseline, an association was found between: p-NGV and symbol-digit (SDMT) (p = 0.022); temporal-RNFL and NBV (p = 0.007), NWV (p = 0.012), NGV (p = 0.048), and p-NGV (p = 0.021); papillo-macular bundle-RNFL and NBV (p = 0.013), NWV (p = 0.02), NGV (p = 0.049), and p-NGV (p = 0.032). Over the observational period, we found a reduction of brain volume (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Longitudinal study
Neurology
genetic structures
Retinal nerve Fiber layer thickness
lcsh:RC346-429
Retina
BICAMS
Multiple sclerosis
03 medical and health sciences
0302 clinical medicine
Multiple Sclerosis, Relapsing-Remitting
Nerve Fibers
Ophthalmology
medicine
Humans
Neurochemistry
Cognitive Dysfunction
Longitudinal Studies
lcsh:Neurology. Diseases of the nervous system
Brain volume
business.industry
Brain
Cognition
BICAMS, Brain volume, Cognitive impairments, Multiple sclerosis, Retinal nerve Fiber layer thickness, Neurology (clinical)
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
eye diseases
Cross-Sectional Studies
Brain size
030221 ophthalmology & optometry
Biomarker (medicine)
Female
Neurology (clinical)
Neurosurgery
sense organs
business
030217 neurology & neurosurgery
Tomography, Optical Coherence
Cognitive impairments
Research Article
Subjects
Details
- ISSN :
- 14712377
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC neurology
- Accession number :
- edsair.doi.dedup.....0b48135a684251771abd1289eb7ba741