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Notch Signaling Regulation in Autoinflammatory Diseases

Authors :
Sergio Crovella
Rossella Gratton
Paola Maura Tricarico
Almerinda Agrelli
Adamo Pio D'Adamo
Luisa Zupin
Lucas André Cavalcanti Brandão
Ronald Moura
Anna Monica Bianco
Gratton, Rossella
Tricarico, Paola Maura
D'Adamo, Adamo Pio
Bianco, Anna Monica
Moura, Ronald
Agrelli, Almerinda
Brandão, Luca
Zupin, Luisa
Crovella, Sergio
Source :
International Journal of Molecular Sciences, Vol 21, Iss 8847, p 8847 (2020), International Journal of Molecular Sciences
Publication Year :
2020

Abstract

Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.

Details

Language :
English
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences, Vol 21, Iss 8847, p 8847 (2020), International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....0b462916d8f64e2db2ace1ca04801dc0