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Notch Signaling Regulation in Autoinflammatory Diseases
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 8847, p 8847 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
-
Abstract
- Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.
- Subjects :
- 0301 basic medicine
Cell signaling
Giant Cell Arteritis
Notch pathway
Notch signaling pathway
Inflammation
Review
Cell fate determination
Biology
Catalysis
Inorganic Chemistry
Pathogenesis
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Gene
lcsh:QH301-705.5
Spectroscopy
Receptors, Notch
Behcet Syndrome
Hereditary Autoinflammatory Diseases
Organic Chemistry
autoimmunity
Cell Differentiation
General Medicine
autoinflammation
autoinflammatory diseases
Hidradenitis Suppurativa
Computer Science Applications
Cell biology
Crosstalk (biology)
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Mutation
medicine.symptom
genetic
Intracellular
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 21, Iss 8847, p 8847 (2020), International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....0b462916d8f64e2db2ace1ca04801dc0