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Antiemetic activity of high-dose methylprednisolone associated with continuous-infusion metoclopramide and oral alprazolam during multiple-day chemotherapy
- Source :
- Cancer chemotherapy and pharmacology. 28(1)
- Publication Year :
- 1991
-
Abstract
- The addition of high-dose methylprednisolone (120 mg given i.v. and repeated after a 4-h interval) to a conventional antiemetic regimen consisting of metoclopramide (0.5 mg/kg given as an i.v. bolus over 30 min followed by 1 mg/kg given as a continuous infusion over 24 h) and alprazolam (0.5 mg given p.o.) was evaluated in a randomized study of leukemic patients undergoing anthracycline-containing multiple-day chemotherapy. Double-blind analysis was done in 30 patients who completed a total of 40 treatment courses. Cumulative 3-day results revealed complete control of nausea in 66% of patients and complete control of emesis in 77% of cases. The addition of methylprednisolone significantly reduced the occurrence of nausea (p = 0.003) and emesis (P = 0.06). Moreover, antiemetic rescue with chlorpromazine was less frequently necessary in patients receiving corticosteroids (P = 0.02). No harmful side effect was observed, and the incidence of severe infectious episodes was similar in both arms. We conclude that high-dose methylprednisolone can improve the efficacy of metoclopramide and alprazolam in controlling nausea and emesis induced by anthracycline-containing multiple-day chemotherapy in patients with acute myeloblastic leukemia.
- Subjects :
- Adult
Cancer Research
Time Factors
Metoclopramide
Adolescent
medicine.drug_class
Nausea
Vomiting
medicine.medical_treatment
Toxicology
Methylprednisolone
Bolus (medicine)
Double-Blind Method
Antineoplastic Combined Chemotherapy Protocols
Medicine
Antiemetic
Humans
Pharmacology (medical)
Chlorpromazine
Aged
Pharmacology
Aged, 80 and over
Chemotherapy
Alprazolam
business.industry
Middle Aged
Leukemia, Myeloid, Acute
Oncology
Anesthesia
Drug Therapy, Combination
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 03445704
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer chemotherapy and pharmacology
- Accession number :
- edsair.doi.dedup.....0b38ae6feceaac0ce8274da17307415d