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Cortical plasticity following surgical extension of lower limbs
- Publication Year :
- 2006
- Publisher :
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006.
-
Abstract
- Human cortical plasticity has been studied after peripheral sensory alterations due to amputations or grafts, while sudden 'quasi-physiological' changes in the dimension of body parts have not been investigated yet. We examined the cortical reorganization in achondroplastic dwarfs submitted to progressive elongation (PE) of lower limbs through the Ilizarov technique. This paradigm is ideal for studying cortical plasticity because it avoids the perturbation connected with deafferentation and re-afferentation. Somatosensory evoked-potentials (SEP) and fMRI studies were performed before and after PE during foot and knee stimulation, above and below the surgical fracture. A body schema test was also performed. Following PE, cortical modifications were observed in the primary somatosensory cortex for foot stimulation and in higher order somatosensory cortices for foot and knee. The former modifications tended to decrease 6 months after the elongation ending, whereas the latter tended to persist. Results are interpreted in terms of cortical adaptation mediated by temporary disorganization.
- Subjects :
- Male
Adolescent
Cognitive Neuroscience
fmri
Stimulation
Sensory system
source analysis
Ilizarov Technique
ilizarov
Somatosensory system
Brain mapping
sep
co-registration
Reference Values
Evoked Potentials, Somatosensory
Neuroplasticity
achondroplasia
Body Image
Image Processing, Computer-Assisted
Humans
Dominance, Cerebral
Muscle, Skeletal
mri
Neuronal Plasticity
Tibia
Somatosensory Cortex
Anatomy
Magnetic Resonance Imaging
Body Height
Peripheral
cerebral plasticity
Neurology
Body schema
Somatosensory evoked potential
brain mapping
Female
Psychology
Neuroscience
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0b321a36d63b61227bca8caeaaf24043