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HIV-1 Vpr: Regulator of Viral Survival
- Source :
- ResearcherID
- Publication Year :
- 2009
- Publisher :
- Bentham Science Publishers Ltd., 2009.
-
Abstract
- The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from long-term nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.
- Subjects :
- Programmed cell death
Cell cycle checkpoint
viruses
Regulator
virus diseases
vpr Gene Products, Human Immunodeficiency Virus
biochemical phenomena, metabolism, and nutrition
Biology
Virus Replication
Virology
Immune tolerance
Cell biology
Infectious Diseases
Immune system
Viral replication
Apoptosis
Transcription (biology)
HIV-1
Immune Tolerance
Humans
Subjects
Details
- ISSN :
- 1570162X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Current HIV Research
- Accession number :
- edsair.doi.dedup.....0b317fcaab979922a4716ffd10f3f0d1