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Lymphocyte phenotypes and infection incidence in transfused preterm neonates
- Source :
- Transfusion Medicine. 6:329-336
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- SUMMARY. The immunomodulating effects of repeated exposure to blood from multiple donors coupled with an immature immune system may predispose the preterm neonate to an increased incidence of infection in his first few months of life. To test this hypothesis, we compared lymphocyte phenotypes, serum IgG concentrations, and histories of infection and rehospitalization in neonates at 4 months corrected age. Two of the study groups were preterm infants who had been transfused with either frozen, deglycerolized or CMV-negative, γ-irradiated blood. Control groups consisted of nontransfused term and preterm infants. There were no differences found in lymphocyte phenotypes or serum IgG concentrations of controls or transfused infants. No differences were found in the infection or rehospitalization incidence in the transfused infants as compared with nontransfused preterm neonates. We failed to show differences in immune parameters or in infection and rehospitalization rates of the preterm infants analysed. Alongside previously published reports, our data suggest that red cell transfusions have a minimal impact on the immature immune system of the neonate.
- Subjects :
- Male
Study groups
Red Cell
Incidence (epidemiology)
Lymphocyte
Infant, Newborn
Transfusion Reaction
Hematology
Biology
Flow Cytometry
Communicable Diseases
Phenotype
Immunophenotyping
Immune system
medicine.anatomical_structure
Corrected Age
Immunoglobulin G
Immunology
medicine
Humans
Female
Lymphocytes
Infant, Premature
Lymphocyte subsets
Subjects
Details
- ISSN :
- 13653148 and 09587578
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Transfusion Medicine
- Accession number :
- edsair.doi.dedup.....0b17ee24a5bab41755cc2701a8da13be