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The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease
- Source :
- Toxins, Vol 10, Iss 4, p 155 (2018), Toxins, Toxins, MDPI, 2018, 10 (4), pp.12. ⟨10.3390/toxins10040155⟩, Toxins, 2018, 10 (4), pp.12. ⟨10.3390/toxins10040155⟩, Toxins 4 (10), . (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- International audience; Uremic retention solutes (URS) are associated with cardiovascular complications and poor survival in chronic kidney disease. The better understanding of the origin of a certain number of these toxins enabled the development of new strategies to reduce their production. URS can be classified according to their origins (i.e., host, microbial, or exogenous). The discovery of the fundamental role that the intestinal microbiota plays in the production of many URS has reinstated nutrition at the heart of therapeutics to prevent the accumulation of URS and their deleterious effects. The intestinal microbiota is personalized and is strongly influenced by dietary habits, such as the quantity and the quality of dietary protein and fibers. Herein, this review out lines the role of intestinal microbiota on URS production and the recent discoveries on the effect of diet composition on the microbial balance in the host with a focus on the effect on URS production.
- Subjects :
- 0301 basic medicine
insuffisance rénale
intestinal microbiota
Health, Toxicology and Mutagenesis
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
uremic toxins
030232 urology & nephrology
Physiology
lcsh:Medicine
Trimethylamine N-oxide
Review
Gut flora
Toxicology
chronic kidney disease
pro
prebiotics
vegetarian diet
low protein diet
nutrient composition
chemistry.chemical_compound
0302 clinical medicine
uremie
pro/prebiotics
biology
3. Good health
[SDV] Life Sciences [q-bio]
régime alimentaire
toxine
Food Science & Technology
chronic-renal-failure
Context (language use)
03 medical and health sciences
low-protein-diet
Low-protein diet
oligosaccharides
hemodialysis-patients
p-cresyl sulfate
medicine
Animals
Humans
Renal Insufficiency, Chronic
indoxyl sulfate
nephrectomized rats
Toxicologie
Uremia
trimethylamine-n-oxide
Diet composition
lcsh:R
biology.organism_classification
medicine.disease
Diet
Gastrointestinal Microbiome
arabinoxylan
030104 developmental biology
Dietary protein
chemistry
Red meat intake
microflore digestive
red meat intake
plasma homocysteine
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....0afeaed9ef18c130e56777478f5e2e9e