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Vitamin D status and pathway genes in five European autoimmune Addison’s disease cohorts
- Source :
- European Journal of Endocrinology. 184:373-381
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Objective While vitamin D regulates immune cells, little is known about it in autoimmune Addison’s disease (AAD). We investigated the vitamin D status in AAD patients from five European populations to assess its deficiency. In addition, we studied two case-control cohorts for vitamin D metabolism and pathway genes. Design Cross-sectional study. Methods A total of 1028 patients with AAD from Germany (n = 239), Italy (n = 328), Norway (n = 378), UK (n = 44) and Poland (n = 39) and 679 controls from Germany (n = 301) and Norway (n = 378) were studied for 25(OH)D3 (primary objective). Secondary objectives (1,25(OH)2D3 and pathway genes) were examined in case-controls from Germany and Norway correlating 25(OH)D3 and single nucleotide polymorphisms within genes encoding the vitamin D receptor (VDR), 1-α-hydroxylase (CYP27B1), 25-hydroxylase (CYP2R1), 24-hydroxylase (CYP24A1) and vitamin D binding protein (GC/DBP). Results Vitamin D deficiency (25(OH)D3 10–20 ng/mL) was highly prevalent in AAD patients (34–57%), 5–22% were severely deficient (30 ng/mL). Lower 25(OH)D3 and 1,25(OH)2D3 levels were observed both in Norwegian and German AAD (P = 0.03/0.003 and P = 1 × 10-5/< 1 × 10-7, respectively) the former was associated with CYP2R1 (rs1553006) genotype G. Whereas controls achieved sufficient median 25(OH)D3 in summers (21.4 to 21.9 ng/mL), AAD patients remained largely deficient (18.0 to 21.2 ng/mL) and synthesize less 1,25(OH)2D3. Conclusion Vitamin D deficiency and insufficiency are highly prevalent in AAD patients. The vitamin D status of AAD may be influenced by genetic factors and suggests individual vitamin D requirements throughout the year.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Calcitriol
Vitamin D-binding protein
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Vitamin D3 24-Hydroxylase
Polymorphism, Single Nucleotide
Calcitriol receptor
vitamin D deficiency
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Addison Disease
CYP24A1
Internal medicine
Receptors
medicine
Vitamin D and neurology
Humans
Polymorphism
Calcifediol
business.industry
Vitamin D-Binding Protein
Single Nucleotide
General Medicine
Middle Aged
Vitamin D Deficiency
medicine.disease
Europe
Cross-Sectional Studies
chemistry
Case-Control Studies
030220 oncology & carcinogenesis
Receptors, Calcitriol
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 184
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....0afb307668f324cf62aeee512ec749d9