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Impaired proteostasis during skeletal muscle aging
- Source :
- Free Radical Biology and Medicine. 132:58-66
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The skeletal muscle is one of the earliest tissues to be affected and to manifest age-related changes such as functional impairment and the loss of mass. Common to these alterations and to most of tissues during aging is the disruption of the proteostasis network by detrimental changes in the ubiquitin-proteasomal system (UPS) and the autophagy-lysosomal system (ALS). In fact, during aging the accumulation of protein aggregates, a process mainly driven by increased levels of oxidative stress, has been observed, clearly demonstrating UPS and ALS dysregulation. Since the UPS and ALS are the two most important pathways for the removal of misfolded and aggregated proteins and also of damaged organelles, we provide here an overview on the current knowledge regarding the connection between the loss of proteostasis and skeletal muscle functional impairment and also how redox regulation can play a role during aging. Therefore, this review serves for a better understanding of skeletal muscle aging in regard to the loss of proteostasis and how redox regulation can impact its function and maintenance.
- Subjects :
- 0301 basic medicine
Aging
Proteasome Endopeptidase Complex
Protein Folding
Functional impairment
Protein aggregation
Biology
medicine.disease_cause
Biochemistry
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Autophagy
medicine
ddc:61
Animals
Humans
Muscle, Skeletal
Tissue homeostasis
Ubiquitination
Skeletal muscle
Cell biology
Oxidative Stress
030104 developmental biology
Proteostasis
medicine.anatomical_structure
Institut für Ernährungswissenschaft
Reactive Oxygen Species
Oxidation-Reduction
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....0af7b388fe0a80cc110e518f62a4f166