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Relationship between plasma uridine and urinary urea excretion
- Source :
- Metabolism: clinical and experimental. 59(3)
- Publication Year :
- 2008
-
Abstract
- To investigate whether the concentration of uridine in plasma is related to the urinary excretion of urea, 45 healthy male subjects with normouricemia and normal blood pressure were studied after providing informed consent. Immediately after collection of 24-hour urine, blood samples were drawn after an overnight fast except for water. The contents of ingested foods during the 24-hour urine collection period were described by the subjects and analyzed by a dietician. Simple regression analysis showed that plasma uridine was correlated with the urinary excretions of urea (R = 0.41, P < .01), uric acid (R = 0.36, P < .05), and uridine (R = 0.30, P < .05), as well as uric acid clearance (R = 0.35, P < .05) and purine intake (R = 0.30, P < .05). In contrast, multiple regression analysis showed a positive relationship only between plasma uridine and urinary excretion of urea. These results suggest that an increase in de novo pyrimidine synthesis leads to an increased concentration of uridine in plasma via nitrogen catabolism in healthy subjects with normouricemia and normal blood pressure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Gout
Endocrinology, Diabetes and Metabolism
Urinary system
Urine
Excretion
chemistry.chemical_compound
Endocrinology
Internal medicine
Blood plasma
medicine
Dietary Carbohydrates
Homeostasis
Humans
Urea
Uridine
Catabolism
Middle Aged
Dietary Fats
Diet
Uric Acid
chemistry
Creatinine
Hypertension
Uric acid
Regression Analysis
Dietary Proteins
Insulin Resistance
Subjects
Details
- ISSN :
- 15328600
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Metabolism: clinical and experimental
- Accession number :
- edsair.doi.dedup.....0ae361fee387afdafcdbbdaedc33e1de