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Studies on the role of lymphocyte-activating factor (Interleukin 1) in antigen-induced lymph node lymphocyte proliferation
- Source :
- Cellular immunology. 54(2)
- Publication Year :
- 1980
-
Abstract
- The in vitro proliferation of primed lymph node lymphocytes (LNL) in response to the soluble antigen ovalbumin (OVA) was dependent upon the presence of adherent cells. Restoration of OVA-induced LNL proliferation could be achieved by addition of highly purified lymphocyte-activating factor (LAF; Interleukin 1, IL 1): LAF (IL 1) did not stimulate LNL proliferation in the absence of the priming antigen or T lymphocytes. Furthermore, treatment of the LNL with antimacrophage serum completely blocked the ability of the LNL to respond to OVA and LAF (IL 1), suggesting that the residual macrophages in the LNL population were necessary to provide an additional function or signal, possibly antigen presentation, in conjunction with LAF (IL 1). These data therefore support the two signal hypothesis of macrophage-mediated lymphocyte activation and demonstrate the ability of LAF (IL 1) to provide one of these signals.
- Subjects :
- Ovalbumin
Immunology
Population
Antigen presentation
Priming (immunology)
Lymphocyte proliferation
Mice
Antigen
medicine
Cell Adhesion
Animals
Lymphocytes
Antigens
education
Lymph node
education.field_of_study
Mice, Inbred C3H
biology
Interleukin
Proteins
Molecular biology
Mice, Inbred C57BL
medicine.anatomical_structure
biology.protein
Female
Lymph Nodes
Cell Division
Interleukin-1
Subjects
Details
- ISSN :
- 00088749
- Volume :
- 54
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cellular immunology
- Accession number :
- edsair.doi.dedup.....0ae0d2b03826e28c1bcae40ce88132b8