Back to Search
Start Over
Genomic Evidence for Bacterial Determinants Influencing Obesity Development
- Source :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health; Volume 14; Issue 4; Pages: 345
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Obesity is a major global public health problem requiring multifaceted interventional approaches including dietary interventions with probiotic bacteria. High-throughput genome sequencing of microbial communities in the mammalian gastrointestinal system continues to present diverse protein function information to understand the bacterial determinants that influence obesity development. The goal of the research reported in this article was to identify biological processes in probiotic bacteria that could influence the mechanisms for the extraction of energy from diet in the human gastrointestinal system. Our research strategy of combining bioinformatics and visual analytics methods was based on the identification of operon gene arrangements in genomes of Lactobacillus species and Akkermansia muciniphila that include at least a gene for a universal stress protein. The two major findings from this research study are related to Lactobacillus plantarum and Akkermansia muciniphila bacteria species which are associated with weight-loss. The first finding is that Lactobacillus plantarum strains have a two-gene operon that encodes a universal stress protein for stress response and the membrane translocator protein (TSPO), known to function in mitochondrial fatty acid oxidation in humans. The second finding is the presence of a three-gene operon in Akkermansia muciniphila that includes a gene whose human mitochondrial homolog is associated with waist-hip ratio and fat distribution. From a public health perspective, elucidation of the bacterial determinants influencing obesity will help in educating the public on optimal probiotic use for anti-obesity effects.
- Subjects :
- 0301 basic medicine
obesity
Operon
Health, Toxicology and Mutagenesis
bacteria
Akkermansia
body weight
Lactobacillus
microbiome
overweight
probiotics
public health
universal stress proteins
Genome
Article
Microbiology
03 medical and health sciences
0302 clinical medicine
Bacterial Proteins
Verrucomicrobia
Humans
Microbiome
Gene
Heat-Shock Proteins
Genetics
biology
Waist-Hip Ratio
Probiotics
Public Health, Environmental and Occupational Health
Gene Expression Regulation, Bacterial
Genomics
biology.organism_classification
Diet
3. Good health
Gastrointestinal Tract
030104 developmental biology
Genome, Bacterial
030217 neurology & neurosurgery
Lactobacillus plantarum
Akkermansia muciniphila
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....0ad9a884b8613d5464da60a61f3f379f