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Pterocarpus marsupium extract extends replicative lifespan in budding yeast
- Source :
- GeroScience
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan. No mTOR inhibitory activity was detected, but several of the treatments affected growth rate and lifespan. The strongest lifespan shortening effects were observed for green tea extract and berberine. The most robust lifespan extension was detected from an extract of Pterocarpus marsupium and another mixture containing Pterocarpus marsupium extract. These findings illustrate the utility of the yeast system for longevity intervention discovery and identify Pterocarpus marsupium extract as a potentially fruitful longevity intervention for testing in higher eukaryotes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-021-00418-x.
- Subjects :
- Aging
Plant Extracts
Pterocarpus
ved/biology
media_common.quotation_subject
Longevity
ved/biology.organism_classification_rank.species
Saccharomyces cerevisiae
Correction
Green tea extract
Biology
Pterocarpus marsupium
biology.organism_classification
Molecular medicine
Yeast
Cell biology
Saccharomycetales
Original Article
Geriatrics and Gerontology
Model organism
PI3K/AKT/mTOR pathway
media_common
Subjects
Details
- ISSN :
- 25092723 and 25092715
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- GeroScience
- Accession number :
- edsair.doi.dedup.....0ad882866b8140dacf583449b1c91f96