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Phenytoin-induced pseudolymphoma. A report of a case and review of the literature
- Source :
- British Journal of Dermatology. 127:403-406
- Publication Year :
- 1992
- Publisher :
- Oxford University Press (OUP), 1992.
-
Abstract
- We report a patient with phenytoin-induced pseudolymphoma mimicking cutaneous T-cell lymphoma (CTCL). Despite withdrawal of phenytoin, there was persistence of the cutaneous eruption and lymphadenopathy. Southern blot analysis of immunoglobulin and T-cell receptor genes was therefore used to assess whether there was a clonal lymphoid expansion. However, no rearrangement of the beta T-cell receptor gene or immunoglobulin heavy-chain gene was detected in tissue DNA from skin and lymph nodes. One year later the patient became asymptomatic, although he is still at risk of developing a true malignant lymphoma in the future, a condition known as pseudo-pseudolymphoma. It is suggested that genotypic studies may help in the initial diagnosis and the subsequent management of such patients.
- Subjects :
- Adult
Male
Phenytoin
Pathology
medicine.medical_specialty
Lymphoma
T cell
Dermatology
Asymptomatic
Diagnosis, Differential
Pseudolymphoma
medicine
Humans
Southern blot
biology
business.industry
medicine.disease
Lymphoma, T-Cell, Cutaneous
medicine.anatomical_structure
Immunology
biology.protein
Lymph
Antibody
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 13652133 and 00070963
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- British Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....0ad6ec0f8372264b0277e7772daa0d12