Supplmental Figures S1 - S8 from Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

Supplemental Figure S1. Further characterization of the small-molecule Informer Set and comparisons between CTRP v1 and v2. Supplemental Figure S2. Cellular features of the CCL panel. Supplemental Figure S3. Details on ACME analysis described in this paper. Supplemental Figure S4. ACME identifies clinically relevant associations between small-molecule sensitivity and cancer cell features. Supplemental Figure S5. Using ACME to investigate small-molecule mechanism of action. Supplemental Figure S6. Microtubule regrowth assay in NCIH661 cells. Supplemental Figure S7. Combined IGF1R and ALK inhibition in ALK overexpressed neuroblastoma. Supplemental Figure S8. Using ACME to inform combination screening.