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Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe
- Source :
- Antimicrobial agents and chemotherapy. 62(9)
- Publication Year :
- 2018
-
Abstract
- The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan- aminoglycoside-, or polymyxin-resistant Enterobacteriaceae. A total of 36 isolates (including 30 Escherichia coli and 4 Klebsiella pneumoniae) were recovered from 23 patients, including 26 isolates harboring the blaOXA-181 carbapenemase gene, a single isolate harboring the 16S rRNA methylase gene rmtB encoding pan-resistance to aminoglycosides, and 8 isolates coharboring both genes. A single isolate possessed the plasmid-borne colistin resistance gene mcr-1. A high clonal relationship was found for OXA-181-producing E. coli (4 clones), and conversely, three of the four OXA-181-producing K. pneumoniae isolates were clonally unrelated. This study overall showed a high prevalence of resistance to last-resort antibiotics in this country, where no epidemiological data were previously available.
- Subjects :
- 0301 basic medicine
Carbapenem
medicine.drug_class
Klebsiella pneumoniae
Polymyxin
030106 microbiology
Antibiotics
Sao Tome and Principe
Microbial Sensitivity Tests
beta-Lactamases
Microbiology
03 medical and health sciences
Plasmid
Bacterial Proteins
Mechanisms of Resistance
Drug Resistance, Multiple, Bacterial
RNA, Ribosomal, 16S
medicine
Escherichia coli
Humans
Pharmacology (medical)
Polymyxins
Pharmacology
biology
Colistin
Escherichia coli Proteins
Methyltransferases
biology.organism_classification
16S ribosomal RNA
Enterobacteriaceae
Anti-Bacterial Agents
Infectious Diseases
Aminoglycosides
Carbapenems
medicine.drug
Plasmids
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 62
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....0ad42cfbab9054e31fffbfae2160176c