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Mechanisms in regulating the release of serotonin from the perfused rat stomach
- Source :
- American journal of physiology. Gastrointestinal and liver physiology. 280(6)
- Publication Year :
- 2001
-
Abstract
- The mechanisms regulating the release of serotonin into the portal circulation as well as into the gastric lumen were studied in the isolated vascularly and luminally perfused rat stomach. Immunohistochemical study of the rat stomach showed that serotonin-containing enterochromaffin (EC) cells were densely packed in the antral mucosa, sparsely scattered in the corpus, and not found in the fundus. Such morphological findings suggest that serotonin detected in this study may have originated from antral EC cells. Luminal acidification stimulated the vascular release of serotonin but did not affect the luminal release of serotonin. The basal release of serotonin into the vasculature was 10 times higher than that into the gastric lumen at intragastric pH 2. The vascular release of serotonin is regulated by stimulation from cholinergic nicotinic mechanisms, whereas inhibitory neurotransmitters such as vasoactive intestinal peptide and NO are probably not involved. Somatostatin and peptide YY originating from endocrine cells may exert direct inhibitory effects, possibly via somatostatin and peptide YY receptors on the EC cells, and a cholinergic muscarinic mechanism may exert indirect effects on the vascular release of serotonin via the muscarinic receptor on the endocrine cells.
- Subjects :
- Male
medicine.medical_specialty
Serotonin
Physiology
Vasoactive intestinal peptide
Cholinergic Agents
Enteroendocrine cell
Biology
In Vitro Techniques
Nitric Oxide
chemistry.chemical_compound
Physiology (medical)
Internal medicine
medicine
Enterochromaffin Cells
Pyloric Antrum
Animals
Rats, Wistar
Neurotransmitter
Hepatology
Stomach
Gastroenterology
Hydrogen-Ion Concentration
Immunohistochemistry
Hormones
Rats
Perfusion
Somatostatin
Endocrinology
chemistry
Gastric Mucosa
Peptide YY
Enterochromaffin cell
Cholinergic
Acids
Vasoactive Intestinal Peptide
Subjects
Details
- ISSN :
- 01931857
- Volume :
- 280
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American journal of physiology. Gastrointestinal and liver physiology
- Accession number :
- edsair.doi.dedup.....0ad3dd77b29583dcf7943621cb056f31