Back to Search
Start Over
Clinical and cytogenetic studies of two cases of Klinefelter syndrome with hereditary retinoblastoma and rhabdomyosarcoma
- Source :
- Cancer Genetics and Cytogenetics. 89:77-81
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Two children with Klinefelter syndrome (KS), one associated with bilateral hereditary retinoblastoma (RB) and the other with rhabdomyosarcoma (RMS) are reported. Both were boys and chromosomally mosaic for KS. The hereditary retinoblastoma case yielded 46,XY,del(13)(q12q14.2)/47, XXY(c),del(13)(q12q14.2) in PHA-stimulated lymphocytes. The rhabdomyosarcoma case yielded 46,XY/ 47,XXY(c) in peripheral blood cells whereas tumor revealed trisomy 8, trisomy 7, and t(7;13)(q33;q32) in addition to 46,XY/47,XXyc mosaicism.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Pathology
Aneuploidy
Biology
Trisomy 8
Klinefelter Syndrome
Internal medicine
Rhabdomyosarcoma
Genetics
medicine
Humans
Molecular Biology
Chromosome Aberrations
Chromosome 7 (human)
Chromosomes, Human, Pair 13
Retinoblastoma
Eye Neoplasms
Cytogenetics
medicine.disease
Endocrinology
Child, Preschool
Hereditary Retinoblastoma
Klinefelter syndrome
Chromosomes, Human, Pair 7
Subjects
Details
- ISSN :
- 01654608
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Cancer Genetics and Cytogenetics
- Accession number :
- edsair.doi.dedup.....0ac4ec03a5c139a619b6080ce4fe02b0