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Proneurogenic Effects of Trazodone in Murine and Human Neural Progenitor Cells
- Source :
- ACS Chemical Neuroscience. 8:2027-2038
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- Several antidepressants increase adult hippocampal neurogenesis (ahNG) in rodents, primates, and, potentially, humans. This effect may at least partially account for their therapeutic activity. The availability of antidepressants whose mechanism of action involves different neurotransmitter receptors represents an opportunity for increasing our knowledge on their distinctive peculiarities and for dissecting the contribution of receptor subtypes in ahNG modulation. The aim of this study was to evaluate, in vitro, the effects of the antidepressant trazodone (TZD) on ahNG by using primary cultures of murine adult hippocampal neural progenitor cells (ahNPCs) and human induced pluripotent stem cell (iPSC)-derived NPCs. We demonstrated that TZD enhances neuronal differentiation of murine as well as human NPCs. TZD is a multimodal antidepressant, which binds with high affinity to 5-HT2a, α1, and 5-HT1a and with lower affinity to 5-HT2c, α2 and 5-HTT. We demonstrated that TZD proneurogenic effects were mediated b...
- Subjects :
- Male
0301 basic medicine
Serotonin
Cell Survival
Physiology
Neurogenesis
Cognitive Neuroscience
Induced Pluripotent Stem Cells
Active Transport, Cell Nucleus
Biology
Hippocampal formation
Hippocampus
Biochemistry
03 medical and health sciences
0302 clinical medicine
Neural Stem Cells
Neurotransmitter receptor
Receptor, Serotonin, 5-HT2C
medicine
Animals
Humans
Receptor, Serotonin, 5-HT2A
Receptor
Induced pluripotent stem cell
Cells, Cultured
Cell Proliferation
Neurons
Dose-Response Relationship, Drug
NF-kappa B p50 Subunit
Cell Biology
General Medicine
Antidepressive Agents
Neural stem cell
Mice, Inbred C57BL
030104 developmental biology
Mechanism of action
Trazodone
Serotonin 5-HT2 Receptor Antagonists
Antidepressant
medicine.symptom
Neuroglia
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19487193
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- ACS Chemical Neuroscience
- Accession number :
- edsair.doi.dedup.....0abf9117d923e9af9cf5320156426c7e