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Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Authors :
Peng Zhang
Guangming Zeng
Piao Xu
Zhuotong Zeng
Biao Song
Maocai Shen
Ming Chen
Huan Yi
Rong Xiao
Ji-Lai Gong
Source :
Environment International, Vol 126, Iss, Pp 598-610 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its human health risks over the past decade. In vivo and in vitro studies are important and effective means to ascertain the toxic effects of PFOS on humans and its toxic mechanisms. This article systematically reviews the human health risks of PFOS based on the currently known facts found by in vivo and in vitro studies from 2008 to 2018. Exposure to PFOS has caused hepatotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity, thyroid disruption, cardiovascular toxicity, pulmonary toxicity, and renal toxicity in laboratory animals and many in vitro human systems. These results and related epidemiological studies confirmed the human health risks of PFOS, especially for exposure via food and drinking water. Oxidative stress and physiological process disruption based on fatty acid similarity were widely studied mechanisms of PFOS toxicity. Future research for assessing the human health risks of PFOS is recommended in the chronic toxicity and molecular mechanisms, the application of various omics, and the integration of toxicological and epidemiological data. Keywords: PFOS, Human health risk, In vivo, In vitro

Details

Language :
English
ISSN :
01604120
Volume :
126
Database :
OpenAIRE
Journal :
Environment International
Accession number :
edsair.doi.dedup.....0ab5a363341bdd9294b7d5a3315f94d8