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Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD
- Source :
- Journal of Clinical Psychiatry, 71(12), 1636-1644. AIP Press, Journal of clinical psychiatry, 71(12), 1636-1644. Physicians Postgraduate Press Inc., Thomaes, K, Dorrepaal, E, Draijer, P J, de Ruiter, M B, van Balkom, A J L M, Smit, J H & Veltman, D J 2010, ' Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD ', Journal of Clinical Psychiatry, vol. 71, no. 12, pp. 1636-1644 . https://doi.org/10.4088/JCP.08m04754blu, Journal of Clinical Psychiatry, 71(12), 1636-1644. Physicians Postgraduate Press Inc.
- Publication Year :
- 2008
-
Abstract
- Objective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD a severe form of PTSD with affect dysregulation and high comorbidity-showed similar brain volume reductions. Method: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28). Complex PTSD was diagnosed using the Structured Clinical Interview for DSM-IV-TR and the Structured Clinical Interview for Disorders of Extreme Stress. All respondents were scanned on a 1.5-T magnetic resonance system at the VU Medical Center, Amsterdam, The Netherlands, between September 2005 and February 2006. Results: As was hypothesized, patients with child abuse-related complex PTSD showed reductions in gray matter concentration in right hippocampus (P-SVC (corrected) = .04) and right dorsal ACC (P-SVC (corrected) = .02)compared to controls. In addition, a reduction in gray matter concentration in the right orbitofrontal cortex (OFC) was found. Severity of child abuse and PTSD-hyperarousal correlated negatively with ACC volume. Impulsivity correlated negatively with hippocampus volume, and anger, with hippocampus and OFC volume. Comorbidity of borderline personality disorder compared to comorbid cluster C personality disorder accounted for more extensive reductions in the ACC and OFC volume. Conclusions: In complex PTSD, not only the hippocampus and the ACC but also the OFC seem to be affected, even in the absence of comorbid borderline personality disorder. These results suggest that neural correlates of complex PTSD are more severe than those of classic PTSD. J Clin Psychiatry 2010;71(12):1636-1644 (C) Copyright 2010 Physicians Postgraduate Press, Inc
- Subjects :
- Child abuse
Adult
medicine.medical_specialty
SDG 16 - Peace
Poison control
Comorbidity
Anger
Impulsivity
Amygdala
behavioral disciplines and activities
Gyrus Cinguli
Hippocampus
Personality Disorders
Severity of Illness Index
Functional Laterality
Stress Disorders, Post-Traumatic
Borderline Personality Disorder
mental disorders
medicine
Image Processing, Computer-Assisted
Humans
Child Abuse
Psychiatry
Child
Borderline personality disorder
Anterior cingulate cortex
Cerebral Cortex
SDG 16 - Peace, Justice and Strong Institutions
medicine.disease
Personality disorders
Magnetic Resonance Imaging
Justice and Strong Institutions
Frontal Lobe
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
medicine.anatomical_structure
nervous system
Case-Control Studies
Impulsive Behavior
Orbitofrontal cortex
Female
medicine.symptom
Psychology
Clinical psychology
Subjects
Details
- ISSN :
- 15552101, 16361644, and 01606689
- Volume :
- 71
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical psychiatry
- Accession number :
- edsair.doi.dedup.....0ab45f6501ec51473d0cee0dbe598cb7